Therapeutic response of cysteamine in the treatment of melasma

Franciely Vanessa Costa, Letícia Silva de Souza, Pâmela Raquel Conradesque, Priscila Carniel

Abstract


The aim of this study was to evaluate how the use of cysteamine in the treatment of melasma has been studied in the literature. This is a qualitative research of the type integrative review to identify productions on topics associated with topical treatment of melasma with cysteamine. The search for the articles was carried out through the Scopus, Science Direct and Pubmed databases using the terms: “melasma” and “cysteamine” and corresponding terms in Portuguese. The research followed the inclusion criteria: a) articles b) be available in full text c) time frame from 01/01/2010 to 31/03/2020 d) studies available in Portuguese, English or Spanish. As exclusion criteria, texts that were unrelated to the theme or had duplicates were disregarded. Of the amount of 11 articles presented, 6 were selected by affinity to the search theme, with 5 articles excluded by the aforementioned criteria. The therapeutic response of cysteamine for the treatment of melasma is positive, reducing hyperpigmented lesions and with controllable adverse effects over the duration of treatment. There was no evidence of the use of cysteamine associated with other active substances or dermatological procedures.


Keywords


Melasma; Hypermelanosis; Cysteamine.

References


Agostinho, G. L. P. L., Oliveira, R. T. G. de, Urzedo, A. P. da S., Cunha, M. G. da, & Machado Filho, C. D. S. (2018). Avaliação comparativa do tratamento de melasma com microagulhamento associado ou não ao drug delivery. Surgical & Cosmetic Dermatology, 10(3), 216–220.

Alster, T. S., & Graham, P. M. (2018). Microneedling: A review and practical guide. Dermatologic Surgery, 44(3), 397–404.

Atallah, C., Charcosset, C., & Greige-Gerges, H. (2020). Challenges for cysteamine stabilization, quantification, and biological effects improvement. Journal of Pharmaceutical Analysis.

Austin, E., Nguyen, J. K., & Jagdeo, J. (2019). Topical Treatments for Melasma: A Systematic Review of Randomized Controlled Trials. Journal of Drugs in Dermatology, 18(2), 1156–1171.

Braghiroli, C. S., & Conrado, L. A. (2018). Microagulhamento e distribuição transepidérmica de drogas. Surgical & Cosmetic Dermatology, 10(4), 289–297.

Diosti, G. de M., Mulinari-Brenner, F., Neto, J. F., Werner, B., do Nascimento, A., & Piva, F. M. (2012). Avaliação clínica e histológica de pacientes com melasma refratário tratadas com laser de érbio: Yag fracionado. Surgical and Cosmetic Dermatology, 4(1), 114–120.

Farshi, S., Mansouri, P., & Kasraee, B. (2018). Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study. Journal of Dermatological Treatment, 29(2), 182–189.

Grimes, P. E., Ijaz, S., Nashawati, R., & Kwak, D. (2019). New oral and topical approaches for the treatment of melasma. International Journal of Women’s Dermatology, 5(1), 30–36.

Kalil, C. L. P. V., Reinehr, C. P. H., & Milman, L. de M. (2017). Luz Intensa Pulsada: Revisão das indicações clínicas. Surgical and Cosmetic Dermatology, 9(1), 9–16.

Kasraee, B., Mansouri, P., & Farshi, S. (2019). Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman’s formula. Journal of Cosmetic Dermatology, 18(1), 293–295.

Lima, E. D. A. (2015). Microagulhamento em melasma facial recalcitrante: uma série de 22 casos *. Anais Brasileiros de Dermatologia, 90(6), 917–919.

Mansouri, P., Farshi, S., Hashemi, Z., & Kasraee, B. (2015). Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: A randomized double-blind placebo-controlled trial. British Journal of Dermatology, 173(1), 209–217.

McKesey, J., Tovar-Garza, A., & Pandya, A. G. (2019). Melasma Treatment: An Evidence-Based Review. American Journal of Clinical Dermatology.

Miot, L. D. B., Miot, H. A., Da Silva, M. G., & Marques, M. E. A. (2009). Fisiopatologia do melasma. Anais Brasileiros de Dermatologia, 84(6), 623–635.

Ni, Z., Mu, Y., & Gulati, O. (2002). Treatment of melasma with Pycnogenol®. Phytotherapy Research, 16(6), 567–571.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica. [e-book]. Ed. UAB/NTE/UFSM. Santa Maria/RS. Disponível em:

http://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-PesquisaCientifica.pdf?sequence=1. Acesso em: 05 Abril 2020.

Pinto, C. A. S., Delfes, M. F. Z., Reis, L. M. dos, Garbers, L. E., Passos, P. C. V. da R., & Torre, D. S. de. (2015). Uso do pycnogenol no tratamento do melasma. Surgical & Cosmetic Dermatology, 7(3), 218–222.

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102–106.

Spadafora, M. C. F. de A., Pereira, Ma. D., Leite, R. S., Yoshida, E. H., & Santos, N. S. dos. (2019). Os benefícios dos despigmentantes para o tratamento do melasma e rejuvenescimento facial. Revista Saúde Em Foco, 599–608.

Steiner, D., Arantes, C., Buzzoni, B., Vinicius, T., Cunha, R., & Urano, A. (2011). Melasma e laser fracionado não ablativo ( 1540nm ): um estudo prospectivo. Surgical & Cosmetic Dermatology, 3(1), 37–40.

Steiner, D., Feola, C., Bialeski, N., & de Morais e Silva, F. A. (2009). Tratamento do melasma: Revisão sistemática. Surgical and Cosmetic Dermatology, 1(2), 87–94.

Wanick, F. B. F., Zink, B. S., & Lopes, R. F. (2011). Avaliação da eficácia do licopeno , beta- caroteno e Lactobacillus johnsonii no tratamento de manutenção do melasma durante o verão : um estudo comparativo. Surgical & Cosmetic Dermatology, 3(4), 297–301.




DOI: http://dx.doi.org/10.33448/rsd-v9i6.3468

Refbacks

  • There are currently no refbacks.


Base de Dados e Indexadores: Base, Diadorim, Sumarios.org, DOI Crossref, Dialnet, Scholar Google, Redib, Doaj, Latindex, Portal de Periódicos CAPES

Research, Society and Development - ISSN 2525-3409

Licença Creative Commons
Este obra está licenciado com uma Licença Creative Commons Atribuição 4.0 Internacional

Rua Irmã Ivone Drumond, 200 - Distrito Industrial II, Itabira - MG, 35903-087 (Brasil) 
E-mail: rsd.articles@gmail.com