Effect of non-surgical periodontal treatment on C-reactive protein, glycated hemoglobin and hyperlipidemia indexes in cardiac patients: a literature review

Quemuel Pereira da Silva, Filipe de Oliveria Lima, Maria Tays Pereira Santana, Thallita Alves dos Santos, Maria Vitoria Oliveira Dantas, Paula Lima Nogueira, Amanda da Silva Araújo, Raiza kelly de Oliveira Araújo, Pedro Paulo de Sousa Pereira, Ítalo Cardoso dos Santos

Abstract


The present study analyzed the scientific literature in search of information that can contribute to the knowledge about the analysis of indexes that are considered factors of predisposition to heart problems after non-surgical periodontal treatment, more specifically lipid profile, glycated hemoglobin ( HbA1c) and C-reactive protein (PCR). As the present study is a literature review, for its production, the databases were consulted: Biblioteca Virtual em Saúde (BVS), Publicações Médicas (PubMed), Medline e biblioteca virtual Scientific Eletronic Library online (SCIELO). To carry out this research, we used the Descritores em Ciência da Saúde (DECS): periodontal diseases, dental scaling and cardiovascular diseases. The review demonstrated the fact that increases in CRP concentration are predictive of cardiovascular diseases (CVDs), and can be directly associated with the progress of atheromatous plaques formed in the carotid arteries. It also showed that untreated periodontitis is associated with possible alterations in lipid metabolism. In addition, lipid alterations in this context would be caused by infection that induces atherogenic changes in lipoprotein profiles. It was also seen that periodontal treatment performed correctly, works as a way to improve the clinical parameters of periodontal disease, as well as to favor the metabolic control of glucose in diabetic individuals, since periodontal disease can mean prognostic value for these cases. It is concluded that with this review there is evidence that non-surgical periodontal treatment can influence the decrease in levels of CRP, HbA1c and hyperlipidemia in patients with CVDs


Keywords


Periodontal diseases; Dental scaling and Cardiovascular diseases.

References


Accarini R. & Godoy F.M. (2006). Doença periodontal como potencial fator de risco para síndromes coronárianas agudas. Associação Brasileira de Cardiologia, 87(5), 592-596.

Bartova J.,Sommerova P., Lyuya-Mi Y., Mysak J., Prochazkoca J.,&Duskova J. (2014).Periodontitis as a risk factor of Atherosclerosis.Journal of Immunology Research, 2014, 1-9.

Bittencourt, M.S.P. (2008). A influência do tratamento periodontal não cirúrgico sobre perfil lipídico e células sanguíneas de pacientes de periodontite crônica generalizada. Tese de doutorado, Rio de Janeiro: Universidade do Estado do Rio de Janeiro; Rio de Janeiro, RJ, Brasil.

Blake G.J. &Ridker P.M. (2003).C-reactive protein and other inflammatory risks markers in acute coronary syndromes.J Am Coll Cardiol, 41(4), 37-42.

Bokhari A.S.H., Khan A.A., Butt A.K., Azhar M., Hanif M., &Izhar M. (2012) Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J ClinPeriodontol, 39(11), 1065-1074.

Çalapkorur M.U., Alkan B.A., Tasdemir Z., Akcali Y., &Saatçi E. (2016). Association of peripheral arterial disease with periodontal disease: analysis of inflammatory cytokines and an acute phase protein in gingival crevicilar fluid and serum. Journalof Periodontal Research, 52(3), 532-539.

Caúla A.L., Lira-Junior R., Tinoco E.M.B., &Fischer R.G. (2014).The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J ClinPeriodontol, 41(9): 875-82.

Chen L., Luo G., Xuan D., Wei B., Liu F.,& Li J. (2012). Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters and metabolic control in patients with type 2 diabetes: a randomized study. J Periodontol, 83(4): 435-443.

Czerniuk M.R, Bartoszewicz Z., Filipiak K.J., Dudzik-Niewiadomska I., Pilecki T., &Górska R. (2016). Plasmatic NT-proBNP concentrations in patients in patients with coexistent periodontal disease and congestive heart failure: pilot studies. KardiologiaPolska, 75(2), 135-42.

D'Aiuto F., Parkar M., Nibali L., Suvan J., Lessem J.,&Tonetti M.S. (2006).Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart J, 151(5), 977-984.

D'Aiuto F., Sabbah W., Netuveli G., Donos N., Hingorani A.D., &Deanfield J. (2008).Association of the Metabolic Syndrome with Severe Periodontitis in a Large U.S. Population-Based Survey.The J ofClinicalEndocrinol&Metabolism, 93(10): 3989-3994.

Ebersole J.L., Nagarajan R., Akers D.& Miller C.S. (2015).Targeted salivary biomarkers for discrimination of periodontal health and disease(s).Frontiers in CellAndInfectMicrobiol, 5, 1-12.

Engebretson S.P., Hyman L.G., Michalowicz B.S., Schoenfeld E.R., Gelato M.C., &Hou W. (2013). The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontites a randomized clinical trial. JAMA, 310(23), 2523-2532.

Fu Y.W., Li X.X., Xu H.Z., Gong Y.Q.& Yang Y. (2016). Effects of periodontal therapy on serum lipid profile and proinflammatory cytokines in patients with hyperlipidemia: randomized controlled trial. Clinical Oral Investigations, 20(6), 1263-1269.

Gay I.C., Tran D.T., Cavender A.C., Weltman R., Chang J.,&Luckenbach E. (2014). The effect of periodontal therapy on glycaemic control in a Hispanic population with type 2 diabetes: a randomized controlled trial. J ClinPeriodontol, 41(7), 673-80.

Górski B., Nargiello E., Opolski G., Ganowicz E.&Górska R. (2016). The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction. AdvClinExpMed, 25(4), 625-630.

Hada D.S., Garg S., Ramteke G.B., &Ratre M.S. (2015). Effect of non-surgical periodontal treatment on clinical and biochemical risk markers of cardiovascular disease: A randomized trial. J Periodontol, 86(11), 1201-11.

Haraszthy V.I., Hariharan G., Tinoco E.M., Cortelli J.R., Lally E.T., &Davis E. (200)Evidence for the role of highly leukotoxicActinobacillusactinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. J Periodontol, 71(6), 912-922.

Herzberg M.C. & Meyer M.W. (1996).Effects of oral flora on platelets: possible consequences in cardiovascular disease. J Periodontol, 67, 1138-1142.

Higashi Y., Goto C., Hidaka T., Soga J., Nakamura S., &Fujii Y. (2009).Oral infection-inflammatory pathway, periodontitis ,ia a risk factor for endothelial dysfunction in patients with coronary artery disease. Atherosclerosis, 206(2), 604-610.

Higashi Y., Goto C., Jitsuiki D., Umemura T., Nishioka K., &Hidaka T. (2008). Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients. Hypertension, 51(2), 446-453.

Jaramillo A., Lafaurie G.I., Millán L.V., Ardila C.M., Duque A.,&Novoa C. (2013). Association between periodontal disease and plasma levels of cholesterol and triglycerides. ColombMedic, 44(2): 80-86.

Kampits C., Montenegro M.M., Ribeiro I.W., Furtado M.V., Polanczyk C.A.,&RösingC.K.(2016). Periodontal disease and inflammatory blood cytokines in patients with stable coronary artery disease.JournalofApplied Oral Science, 24(4): 352-358.

Kiran M., Arpak N., Unsal E.,& Erdogan M.F. (2005).The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus.J ClinPeriodontol, 32(3): 266-272.

Koromantzos P.A., Makrilakis K.,Dereka X., Katsilambros N., Vrotsos I.A,&Madianos P.N. (2011).A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes.Parte I: effect on periodontal status and glycaemic control. J ClinPeriodontol, 38(2), 142-147.

Machado A.C., Quirino M.R., &Nascimento L.F. (2005).Relation between chronic periodontal disease and plasmatic level of triglycerides, total cholesterol and fractions.Brazilian Oral Research, 19(4), 284-89.

Moeintaghavi A., Arab H.R., Bozorgnia Y., Kianoush K., &Alizadeh M. (2012). Non-surgical periodontal therapy affects metabolic control in diabetics: a randomized controlled clinical trial. Aust Dent J, 57(1), 31-37.

Molino-Lova R., Macchi C., Gori A.M., Marcucci R., Polcaro P.,&Cecchi F. (2011).High sensitivity C-reactive protein predicts the development of new carotid artery plaques in older persons. Nutri,MetandCardDiseases, 21(10), 776-82.

Nguyen T.T., Ngo L.Q.,Promsudthi A.,&Surarit R. (2016). Salivary lipid peroxidation in patients with generalized chronic periodontitis and acute coronary syndrome. JofPeriodontology. 87(2), 134-41.

Nibali L., Rizzo M., Li Volti G., D'Aiuto F., Giglio R.V., &Barbagallo I. (2015). Lipid subclasses profiles and oxidative stress in agressive periodontitis before and after treatment.J of Periodontal Res, 50(6), 890-896.

Offenbacher S., Beck J.D., Moss K., Mendoza L., Paquette D.W., &Barrow D.A. (2009). Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol, 80(2), 190-201.

Oz S.G., Fentoglu O., Kilicarslan A., Guven G.S., Tanriover M.D., &Aykac Y. (2007).Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia.Southern Medical Journal, 100(7), 686-691.

Paraskevas S., Huizinga J.D.,&Loos B.G. (2008). A systematic review and meta-analyses on C-reactive protein in relation to periodontitis.J ClinPeriodontol, 35(4), 277-290.

Pereira, D.R. (2010).A influência do tratamento periodontal no controle glicêmico em pacientes diabéticos tipo 2 não insulino-dependentes. Dissertação de mestrado,Universidade do Grande Rio, Duque de Caxias, RJ, Brasil.

Reddy K.S. (1993).Cardiovascular diseases in India.World Health Stat Q, 46(2), 101-107.

Ridker P.M., Hennekens C.H., Buring J.E.,&Rifai N. (2000).C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.N Engl J Med, 342(12), 836-843.

Safranow K.,Dziedziejko V., Rzeuski R., Czyzycka E., Bukowska H., Wojtarowicz A. et al (2016). Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease. PostepyHigMedDosw, 70, 56-66.

Sims T.J., Lernmark A., Mancl L.A., Schifferle R.E., Page R.C., &Persson G.R. (2002). Serum IgG to heat shock proteins and Porphyromonasgingivalis antigens in diabetic patients with periodontitis. J ClinPeriodontol, 29(6), 551-562.

Singh S., Kumar V., Kumar S.,&Subbappa A. (2008). The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Int J of Diabetes in Developing Countries, 28(2), 38-44.

Stewart J.E., Wager K.A., Frieldlander A.H., &Zadeh H.H. (2001). The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. J ClinPeriodontol, 28(4), 306-130.

Teeuw W.J., Slot D.E., Susanto H., Gerdes V.E., Abbas F., D'Aiuto F.et al. (2014). Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J ClinPeriodontol, 41(1), 70-79.

Telgi R.L., Tandon V., Tangade P.S., Tirth A., Kumar S., &Yadav V. (2013). Efficacy of nonsurgical periodontal therapy on glycaemic control in type II diabetic patients: a randomized controlled clinical trial. J Periodontal ImplantSci, 43(4), 177-182.

Vidal F., Cordovil I., Figueiredo C.M.S., &Fischer R.G. (2013).Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J ClinPeriodontol, 40(7): 681-687.

YehE.,&Willerson J. (2003).Coming of age C-reactive protein.Using inflammation markers in cardiology.Circulation, 107(3), 370-71.

Zhou S.Y., Duan X.Q., Hu R., &Ouyang X.Y. (2013).Effect of non-surgical periodontal therapy on serum levels of TNF-α, IL-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease. Clin J Dent Res, 16(2), 145-151.




DOI: http://dx.doi.org/10.33448/rsd-v9i5.3450

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