Nutrients and bioactive compounds in epigenetic modulation associated with prevention and combat cancer

Daniel Pinheiro Fernandes, Vanessa Erika Abrantes Coutinho, Larissa de Brito Medeiros, Neusa Lygia Vilarim Pereira

Abstract


The components present in some foods have the ability to directly influence the health-disease process through epigenetic molecular mechanisms, reducing the risk of developing some diseases, especially Chronic Non-Communicable Diseases (NCDs), such as cancer. In this sense, the present study seeks to elucidate the role of some nutrients and bioactive compounds in food in epigenetic modulation as a way of preventing and fighting cancer. For that, a systematic search was performed in the LILACS, PubMed and BVS databases. The descriptors were used: Epigenomics, Phytochemical Compounds, Neoplasms and Nutrients, all selected according to the Health Sciences Descriptors and used in the languages: Portuguese and English. Initially, 3177 publications were found and after applying the predefined inclusion and exclusion criteria, nine relevant publications remained for the construction of the work. It was verified from the selected literature, that some nutrients and bioactive compounds, such as Curcumin from the turmeric, Sulforaphane and Phenethyl Isothiocyanate (PEITC) from cruciferous vegetables, Resveratrol (RES) from red grapes and wine, β-carotene from orange vegetables, Vitamin C from citrus fruits and some phytochemicals, such as Quercetin and Caffeic acid, play an important role in fighting cancer, as, among other benefits, they can epigenetically stimulate the gene expression of factors preventive measures, but they can also inhibit the expression of factors linked to metastasis and progression of the pathology already installed. Finally, it is clear that the influence that some foods have on gene expression and represents an important tool against cancer, especially in relation to prevention. However, it is necessary to carry out more detailed studies in relation to doses and possible harmful effects.

Keywords


Epigenomics; Phytochemicals; Neoplasms; Nutrients.

References


Andreescu, N, Puiu, M & Niculescu, M. (2018). Effects of Dietary Nutrients on Epigenetic Changes in Cancer. Methods in Molecular Biology, 1856(1), 121-139.

AMERICAN CANCER SOCIETY (2019), Cancer Prevention & Early Detection Facts & Figures 2019-2020. American Cancer Society Inc. 14-32. Disponível em: https://www.cancer.org/research/cancer-facts-statistics/cancer-prevention-early-detection.html

Bishop, K S & Ferguson, L R (2015). The Interaction between Epigenetics, Nutrition and the Development of Cancer. Nutrients, 7(2), 922–947.

Bolaños-Jimenez, F. et al. (2018). Nutrição e Epigenética. In Sawaya, A.L, Leandro, C.G & Waitzberg, D.L (Eds), Fisiologia da Nutrição na Saúde e na Doença: Da Biologia Molecular ao Tratamento (pp. 303-315). São Paulo: Atheneu.

Bonnefont-rousselot, D. (2016). Resveratrol and Cardiovascular Diseases. Nutrients, 8(5), 1-24.

Brasil. (2019). Instituto Nacional do Câncer (INCA). ABC do Câncer: Abordagens Básicas para Controle do Câncer. Brasília. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//livro-abc-5-edicao.pdf Acesso em: 22.novembro.2019.

Castro, R.C.B. et al. (2017). Câncer. In Cominetti, C, Rogero, M.M & Horst, M.A (Eds), Genômica Nutricional: Dos Fundamentos a Nutrição Molecular (pp. 339-355). Barueri: Manole.

Chang, Y. C. et al. (2016). Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression. Oncotarget, 7(11), 12137–12149.

Debusk, R. (2018). Genômica Nutricional. In Mahan, L K & Raymond, J..L. (Eds), Krause: Alimentos, Nutrição e Dietoterapia (pp. 263-345). Rio de Janeiro: Elsevier.

Donovan, M. G., Selmin, O. I., & Romagnolo, D. F. (2018). Aryl Hydrocarbon Receptor Diet and Breast Cancer Risk. The Yale journal of biology and medicine, 91(2), 105–127.

Gillberg et al. (2018). Vitamin C – A new player in regulation of the cancer epigenome. Seminars in Cancer Biology, 51(1), 59-67.

Gomes, C. E. T. & Santos, E. C. (2014). Nutrição e Dietética. (2 ed.). São Paulo: Ericá.

Hamilton, K. K. Grant, B. L. (2018). Dietoterapia para Prevenção e Tratamento do Câncer e Sobreviventes de Câncer. In Mahan, L. K & Raymond, J. L. (Eds), Krause: Alimentos, Nutrição e Dietoterapia (pp. 1349-1394). Rio de Janeiro: Elsevier.

Kelly, A.D. & Issa, J.J. (2017). The promise of epigenetic therapy: reprogramming the cancer epigenome. Current Opinion in Genetics & Development, 42(1), 68-77.

Kim, D., Kim, Y., & Kim, Y. (2019). Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells. Journal of cancer prevention, 24(4), 224–232.

Li, Y., Buckhaults, P., Cui, X., & Tollefsbol, T. O. (2016). Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals. Epigenomics, 8(8), 1019–1037.

Marchioni, D. M. L. Fisberg R. M. (2009). Dieta, Nutrição e Prevenção De Doenças Crônicas Não-Transmissíveis. In Cuppari, L (Ed), Nutrição: nas doenças crônicas não-transmissíveis (pp. 2-25). Barueri: Manole Ltda.

Mingay, M. et al. (2018). Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia. Leukemia, 32(1), 11–20.

Nasir, A. et al. (2019). Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review. Critical Reviews In Food Science And Nutrition, 59(1), 1-13.

Niedzwiecki, A., Roomi, M. W., Kalinovsky, T., & Rath, M. (2016). Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients, 8(9), 552.

Norat, T. el al. (2015). European Code against Cancer 4th Edition: Diet and cancer. Cancer Epidemiology, 39(1), 56-66.

Patrício, R.S.G. & Ong, T. P. (2018). Nutrigenômica. In Sawaya, A.L, Leandro, C.G & Waitzberg, D.L (Eds), Fisiologia da Nutrição: na Saúde e na Doença (pp. 287-291). São Paulo: Atheneu.

Pavan, A. R. et al. (2016). Unraveling the Anticancer Effect of Curcumin and Resveratrol. Nutrients, 8(11), 628.

Qin, S. & Hou, D.‐X. (2016), Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals. Mol. Nutr. Food Res., 60: 1731-1755.

Schmid, L, Soder, T.F & Benetti, F. (2019). NUTRIGENÔMICA COMO FERRAMENTA PREVENTIVA DE DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS. Arquivos de Ciências da Saúde da UNIPAR, 23(2), 127-138.

Silva, H. R. et al. (2020). Análise dos efeitos da suplementação de determinados antioxidantes no tratamento adjuvante do câncer. Research, Society and Development, 9(2), 1-13.

Stacchiotti, A, Favero, G & Rezzani, R. (2019). Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases. Resveratrol - Adding Life To Years, Not Adding Years To Life, 117-135.

Turati et al. (2015). Fruit and vegetables and cancer risk: a review of southern European studies. Br J Nutr, 113(2), 102-110.

Zhang, C. et al. (2016). Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194. Molecular nutrition & food research, 60(6), 1427–1436.




DOI: http://dx.doi.org/10.33448/rsd-v9i4.2914

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