Influence of Magnesium and Calcium on Oxidative Stress in Obesity

Mickael de Paiva Sousa, Kyria Jayanne Clímaco Cruz, Stéfany Rodrigues de Sousa Melo, Diana Stéfany Cardoso de Araujo, Tamires da Cunha Soares, Dilina do Nascimento Marreiro

Abstract


Introduction: Obesity is characterized by excess body fat resulting from the imbalance between food intake and energy expenditure. Studies have shown that excess fat is associated with high-grade oxidative stress. Another important aspect concerns changes in micronutrient concentrations, such as magnesium and calcium, in obese organisms. Research has highlighted a reduction in serum values of these minerals in these individuals, as well as evidencing that in situations of deficiency there appears to be a higher production of reactive oxygen species, contributing to oxidative stress. Therefore, this review aims to provide updated information on the relationship between magnesium, calcium and oxidative stress in obesity. Methodology: A bibliographic survey was performed in the Pubmed, SciELO and LILACS databases, using the following keywords: “calcium”, “magnesium” and “obesity”; Obesity and oxidative stress; "Calcium", "magnesium", "obesity" and "oxidative stress". Results: Obese individuals appear to have magnesium deficiency due to inadequate mineral intake, compromising antioxidant defense mechanisms, as well as contributing to the increase of intracellular calcium, a factor that causes a high production of reactive oxygen species, promoting oxidative stress. Conclusion: The inadequate intake of magnesium contributes to the manifestation of its deficiency in obese, a situation that is linked to changes in calcium metabolism and antioxidant defense system. However, further studies are needed, considering that the metabolism of the studied micronutrients are not completely elucidated.


Keywords


Nutritional Deficiencies; Metabolism; Noncommunicable Chronic Diseases.

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DOI: http://dx.doi.org/10.33448/rsd-v9i1.1776

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