Association between Dietary Magnesium Intake and Lipid Profile Parameters in Obese Women

Mickael Paiva Sousa, Kyria Jayanne Clímaco Cruz, Dilina do Nascimento Marreiro, Jennifer Beatriz Silva Morais, Loanne Rocha dos Santos, Stéfany Rodrigues de Sousa Melo, Ana Raquel Soares de Oliveira, Francisco Erasmo de Oliveira, Gilberto Simeone Henriques

Abstract


Introduction: Obesity is associated with the development of other chronic diseases, such as dyslipidemia, characterized by increased plasma concentrations of triglycerides, total cholesterol (TC) and LDL-c and reduction of HDL-c. In order to identify mechanisms involved in these disorders, magnesium has been studied for regulating important enzymes in lipid metabolism. Objective: To evaluate the relationship between dietary magnesium content and lipid profile in obese women. Methodology: Cross-sectional and analytical study with women divided into two groups: case (obese, n = 25) and control (eutrophic, n = 42). Magnesium intake was analyzed by a three-day food record using the Nutwin program. Serum lipid concentrations were determined according to the colorimetric enzymatic method in an automatic biochemical analyzer. Results: Macronutrient intake values were within the recommended ranges in both groups. Magnesium intake was below the recommendations, with no statistical difference between the studied groups (p> 0.05). Serum TC and LDL-c concentrations were higher and HDL-c lower in obese women compared to eutrophic women (p <0.05). There was a significant negative correlation between dietary magnesium and LDL-c concentrations in the control group (p <0.05). However, there was no correlation between micronutrient intake and lipid profile parameters in the case group. Conclusion: The results do not suggest the participation of magnesium in the protection against changes in lipid profile in obese women.


Keywords


Nutritional Deficiencies; Metabolism; Noncommunicable Chronic Diseases.

References


Al-ajlan, A.R.(2011). Lipid Profile in Relation to Anthropometric Measurements among College Male Students in Riyadh, Saudi Arabia: A Cross-Sectional Study. International Journal of Biomedical Science, 7(2):112-119.

Bain, L.K.M., Myint, P.K., Jennings, A., Lentjes, M.A.H., Luben, R.N., Khaw, K.T., Wareham, N.J & Welch, A.A.(2015). The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort. International Journal of Cardiology,196:108–114.

Barroso, T.A., Marins, L.B., Alves, R., Gonçalves, A.C.S., Barroso, S.G & Rocha, G.S.(2017). Association of Central Obesity with The Incidence of Cardiovascular Diseases and Risk Factors. International Journal of Cardiovascular Sciences, 30(5):416-424.

Bertinato, J., Xiao, C.W., Ratnayake, W.M.N., Fernandez, L., Lavergne, C., Wood, C & Swist, E.(2015). Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men. Food & Nutrition Research, 59.

Casavalle, P.L., Lifshitz, F., Romano, L.S., Pandolfo, N., Caamaño, L.,

Boyer, P.M., Rodríguez, P.N & Friedman, S.M.(2014). Prevalence of dyslipidemia and metabolic syndrome risc factor in overweight and obese children. Pediatric endocrinology reviews, 12(2):213-23.

Chitra, U., Reddy, N.K & Balakrishna, N.(2012). Role of lifestyle variables on the lipid profile of selected South Indian subjects. Indian Heart Journal, 64(1):28–34.

Choi, M.K & Bae, Y.J.(2015). Association of Magnesium Intake with High Blood Pressure in Korean Adults: Korea National Health and Nutrition Examination Survey 2007-2009. PLoS One, 10(6).

Costa, M & Valle, J. (2012). Síndrome metabólica: prevalência e associação com doenças cardiovasculares em adultos. Demetra: Alimentação, Nutrição & Saúde. 7(2):119-32.

Dayrell, C., Urasaki, R., Goulart, R.M.M & Ribeiro, S.M.L.(2009). Consumo alimentar e gasto energético em adolescentes obesos e eutróficos. Revista Paulista de Pediatria, São Paulo, 27(4):374-380.

Elmaoğullari, S., Tepe, D., Uçaktürk, S.A., Kara, F.K & Demirel, F.(2015). Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents. Journal Of Clinical Research İn Pediatric Endocrinology. Sep; 7(3): 228–234.

Geiger, H & Wanner, C. (2012). Magnesium in disease. Clinical Kidney Journal. 5, p:25–38.

Guasch-Ferré, M., Bulló, M., Estruch, R., Corella, D., Martínez- González, M. A., Ros, R., Covas, M., Arós, F., Gómez-Garcia, R., Fiol, M., Lapetra, J., Muñoz, M.A., Serra-Majem, L., Babio, N., Pintó, X., Lamuela- Reventós, R.M., Ruiz-Gutiérrez, V & Salas-Salvadó, S.(2013). Dietary Magnesium Intake Is Inversely Associated with Mortality in Adults at High Cardiovascular Disease Risk. The Journal of Nutrition, p. 55-60.

Institute of Medicine Food and Nutrition Board.(2005). Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press.

Joris, P.J., Plat, J., Bakker, S.J.L., Mensik, R.P.(2017). Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults. Scientific Reports, 7(106).

Ju, S.Y., Choi, W.S., Ock, S.M., Kim, C.M., Kim, D.H.(2014). Dietary Magnesium Intake and Metabolic Syndrome in the Adult Population: Dose-Response Meta- Analysis and Meta- Regression. Nutrients, 6(12):6005-6019.

Kanwar, G & Kabra, R.(2016). A study of association between obesity and lipid profile. Impact Journals. 4(4):69-74.

Khan, M.N & Khaleel, M. (2016). Comparative Study of Serum Lipid Profile of Obese and Non-Obese Students (Male) of Aljouf University. International Journal of Biomedical and Advance Research. 7(1): 035-037.

Kishimoto, Y., Tani, M., Uto-Kondo, H., Saita, E., Iizuka, M., Sone, H & Yokota, K.(2010). Effects of magnesium on postprandial serum lipid responses in healthy human subjects. British Journal of Nutrition. 103 (4):469-72.

Laforest S, Labrecque J, Michaud A, Cianflona K, Ternernof A.(2015). Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction. Critical Reviews in Clinical Laboratory Sciences. 52(6):301-13.

Lefebvre, P., Letois, F., Sultan, A., Nocca, D., Mura, T & Galtier, F.(2014). Nutrient deficiencies in patients with obesity considering bariatric surgery: a cross-sectional study. Surgery for Obesity and Related Diseases. Surgery for Obesity and Related Diseases, 10(3):540-6.

López-Alarcón, M., Perichart-Perera, O., Huerta, S.F., Inda-Icaza, P., Rodríguez-Cruz, M., Armenta-Álvarez, A., Bram-Falcón, M. T & Mayorga-Ochoa, M.(2014). Excessive Refined Carbohydrates and Scarce Micronutrients Intakes Increase Inflammatory Mediators and Insulin Resistance in Prepubertal and Pubertal Obese Children Independently of Obesity. Mediators of Inflammation, 2014(7).

Manjunath, C.N., Rawal, J.R., Irani, P.M & Madhy, K.(2013). Atherogenic dyslipidemia. Indian Journal of Endocrinology and Metabolism, 17(6):969–76.

Oliveira, A.R., Cruz, K.J.C., Morais, J.B.S., Severo, J.S., Freitas, T.E.,

Veras, A.L., Romero, A.B.R., Colli, C., Nogueira, N.N., Leal, F.L.T & Marreiro, D.N. Magnesium status and its relationship with c-reactive protein in obese women. Biological Trace Element Research. 168(2):296-302, 2015.

Oliveira, A.R.S., Cruz, K.J.C., Severo, J.S., Morais, J.B.S., Freitas, T.E.C., Araújo, R.S & Marreiro, D.N.(2017). Hypomagnesemia and its relation with chronic low-grade inflammation in obesity. Revista da Associação Médica Brasileira, 63(2):156-163.

Parto, P & Lavie, C. J.(2017). Obesity and Cardiovascular Diseases. Current Problems in Cardiology, 42(11)p: 376-394.

Pereira, L.S.S., Pinto, R.C.P., Azevedo, V., Muzi1, V.R & Quintão, D.F.(2012). Relação entre perfil antropométrico e a ingestão dietética em pacientes atendidos na clínica escola da faculdade Pitágoras, campus Ipatinga-MG. Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 6(31):4-12.

Ramos-Lopez, O., Milagro, F. I., Allayee, H., Chmurzynska, A., Choi, M. S., Curi, R., De Caterina, R., Ferguson, L.R., Goni, L., Kang, J.X., Kohlmeier, M., Marti, A., Moreno, L.A., Pérusse, L., Prasad, C., Qi, L., Reifen, R., Riezu-Boj, J.I., San Cristóbal, R., Santos, J.L & Martínez, J.A.(2017). Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity. Journal of Nutrigenetics and Nutrigenomics, 10(2):43-62.

Ranganathan, S., Krishnan, T.U.S & Radhakrishnan, S.(2015). Comparison of

dyslipidemia among the normal-BMI and high-BMI group of people of rural Tamil Nadu. Medical Journal of Dr. D.Y. Patil Vidyapeeth. 8(2):149-52.

Rodríguez-Moran, M & Guerrero-Romero, F.(2014). Oral Magnesium Supplementation Improves the Metabolic Profile of Metabolically Obese, Normal-weight Individuals: A Randomized Double-blind Placebo-controlled Trial. Archives of Medical Research, 45(5):388-393.

Sales, C.H., Santos, A.R., Cintra, D.E.C & Colli, C.(2014). Magnesium-deficient high- fat diet: Effects on adiposity, lipid profile and insulin sensitivity in growing rats. Clinical Nutrition, 33(5):879-888.

Singh, R.B., Rastogi, S.S., Sharma, V.K., Saharia, R.B & Kulshretha, S.K.(1990). Can dietary magnesium modulate lipoprotein metabolism? Magnesium and Trace Elements, 9:255–264.

Shahbah, D., Hassan, T., Morsy, S., El Saadany, H., Fathy, M., Al- Ghobashy, A., Elsamad, N., Emam, A., Elhewala, A., Ibrahim, B; El Gebaly, S; El Sayed, H & Ahmed, H.(2017). Oral magnesium supplementation improves glycemic control and lipid profile in children with type 1 diabetes and hypomagnesaemia. Medicine. 96(11).

Simental-Mendía, L.E., Simental-Mendía, M., Sahebkar, A., Rodríguez-Morán, M & Guerrero-Romero, F.(2017). Effect of magnesium supplementation on lipid profile: a systematic review and meta-analysis of randomized controlled trials. European Journal of Clinical Pharmacology. 73(5):525-36.

Venturini, C.D., Engroff, P., Gomes, I & De carli, G. A.(2013). Prevalência de obesidade associada à ingestão calórica, glicemia e perfil lipídico em uma amostra populacional de idosos do Sul do Brasil. Revista Brasileira de Geriatria e Gerontologia, v. 16, n. 3.

Vilchis-Gil, J., Galván-Portillo, M., Klünder-Klünder, M., Cruz, M &

Flores-Huerta, S.(2015). Food habits, physical activities and sedentary lifestyles of eutrophic and obese school children: a case–control study. BMC Public Health, 15(124).

Wang, R., Li, X.N.(2017). Different adipose tissue depots and metabolic syndrome in human. Sheng Li Xue Bao, 69(3):357-365.




DOI: http://dx.doi.org/10.33448/rsd-v9i1.1592

Refbacks

  • There are currently no refbacks.


Base de Dados e Indexadores: Base, Diadorim, Sumarios.org, DOI Crossref, Dialnet, Scholar Google, Redib, Doaj, Latindex, Portal de Periódicos CAPES

Research, Society and Development - ISSN 2525-3409

Licença Creative Commons
Este obra está licenciado com uma Licença Creative Commons Atribuição 4.0 Internacional

Rua Irmã Ivone Drumond, 200 - Distrito Industrial II, Itabira - MG, 35903-087 (Brasil) 
E-mail: rsd.articles@gmail.com